Pono Choices: A Culturally Responsive Teen Pregnancy and STI Prevention Program is a scripted 10 module, 9.5 hour curriculum that provides middle school youth with the knowledge and skills necessary to reduce their risk of unintended pregnancy and STIs by providing medically accurate information within a Native Hawaiian place-based framework. Pono Choices draws from social learning, self-regulation, and developmental assets theories, and it has been developed through a collaborative workgroup process. The program has been reviewed by the Office of Adolescent Health for medical accuracy, is on the Hawai‘i State Department of Education (DOE) approved list of sexual health curricula for grades 6-8, and meets the DOE Abstinence-Based Policy and sexual health and responsibility standards and benchmarks. The program is intended to be delivered where youth ages 11 to 13 in Hawai‘i congregate or go to for sexual health education. Such settings may include schools, community centers, or health clinics. The number of sessions implemented will vary based on the schedules of each site; however, it is strongly recommended for all ten of the lessons to be delivered in their entirety and in sequential order. The Pono Choices curriculum is flexible and has been designed to accommodate individual sites’ schedules so that the recommended sequential delivery may be reached.